Computational Systems Pharmacology and Toxicology by Rudy J. Richardson (English

Description: Computational Systems Pharmacology and Toxicology by Rudy J. Richardson, Dale E. Johnson Estimated delivery 3-12 business days Format Hardcover Condition Brand New Description This book discusses computational tools for modelling pharmacology and toxicology of naturally occurring chemicals. This is a useful reference for students, academics and practitioners. Publisher Description The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug efficacy and safety testing and also reduce the number of animals used in experimentation. Rapid advances in availability of computing technology hold tremendous promise for advancing applied and basic science and increasing the efficiency of risk assessment.This book provides an understanding of the basic principles of computational toxicology and the current methods of predictive toxicology using chemical structures, toxicity-related databases, in silico chemical-protein docking, and biological pathway tools. The book begins with an introduction to systems pharmacology and toxicology and computational tools followed by a section exploring modelling adverse outcomes and events. The second part of the book covers the discovery of protein targets and the characterisation of toxicant-protein interactions. Final chapters include case studies and additionally discuss interactions between phytochemicals and Western therapeutics.This book will be useful for scientists involved in environmental research and risk assessment. It will be a valuable resource for postgraduate students and researchers wishing to learn about key methods used in studying biological targets both from a toxicity and pharmacological activity standpoint. Author Biography Dr Dale E. Johnson is currently an Adjunct Professor in Molecular Toxicology at UC Berkeley and an Adjunct Professor in Environmental Health Sciences at the University of Michigan. He teaches computational toxicology, drug discovery & development, and lectures in pharmacogenomics. He is also President and CEO of Emiliem, Inc. and CEO of Elara Bioscience LLC, a software company. He also consults for biopharmaceutical companies and investment firms. Dr Johnson has over 30 years experience as a research and development scientist, manager, executive, and entrepreneur in the biopharmaceutical field working in large pharmaceutical and biotech companies and several start-ups. Prior to Emiliem, he served as VP Drug Assessment & Development and VP Preclinical Development at Chiron Corporation and previously worked at Hoechst-Roussel Pharmaceuticals, International Research and Development Corp., Medical Research Division of American Cyanamid, Eos Biotechnology and Ddplatform. Dr Rudy J. Richardson is currently the Dow Professor of Toxicology at the University of Michigan. He also holds a joint appointment in the Neurology Department. Sabbatical leaves at Warner-Lambert/Parke-Davis (now Pfizer) in Ann Arbor and the University of Padua in Italy. Dr Richardson has served several times as the Director of the Toxicology Program, and currently he serves as Graduate Chair of the EHS Department. His research interests include computational toxicology, biomarkers and biosensors of exposure and disease, mechanisms of neurodegenerative disease, chemistry and toxicology of organophosphorus and organic nitro compounds, and interactions of toxicants with target macromolecules. Details ISBN 1782623329 ISBN-13 9781782623328 Title Computational Systems Pharmacology and Toxicology Author Rudy J. Richardson, Dale E. Johnson Format Hardcover Year 2017 Pages 347 Publisher Royal Society of Chemistry GE_Item_ID:102466902; About Us Grand Eagle Retail is the ideal place for all your shopping needs! With fast shipping, low prices, friendly service and over 1,000,000 in stock items - you're bound to find what you want, at a price you'll love! Shipping & Delivery Times Shipping is FREE to any address in USA. Please view eBay estimated delivery times at the top of the listing. Deliveries are made by either USPS or Courier. We are unable to deliver faster than stated. 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