Description: Rethinking Cancer by Bernhard Strauss, Marta Bertolaso "Steps toward an explanatory paradigm for cancer that integrates its different levels of organization (molecular, genetic, etc.) and also integrates theoretical and experimental biology with oncology"-- FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence.Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence.Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been so unclear what to do with this knowledge. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence.The contributors first discuss the new research framework in terms of theoretical foundations and then take up the relevance of a systems approach, reviewing such topics as nonlinearity, recurrence after treatment, the cellular attractor concept, network theory, and non-coding DNA--the "dark matter" of our genome. They address the temporality of cancer progression, drawing on evolutionary theory and clinical experience. Finally, they cover the dominant role of the tissue microenvironment in cancer, analyzing topics including altered metabolic pathways, the disease-defining influence on metastasis, and the interconnectedness of different environmental niches across levels of organization. Author Biography Bernhard Strauss is Senior Research Associate at Cambridge University. Marta Bertolaso is Associate Professor of Philosophy of Science, Faculty of Engineering, University Campus Bio-Medico of Rome. Ingemar Ernberg leads the Ingemar Ernberg Group in the Department of Microbiology, Tumor, and Cell Biology at the Karolinska Institutet in Stockholm. Mina J. Bissell is Distinguished Scientist in the Biological Systems and Engineering Division at Lawrence Berkeley National Laboratory. Table of Contents Series Foreword ixPreface xi1 Introduction and Overview 1I REDEFINING THE PROBLEM: THE THEORY DIMENSION OF CANCER 11 2 The Search for Progress and a New Theory Framework in Cancer Research 133 Cancer as a System: Hard Lessons from Physics and a Way Forward 41II THE SYSTEMS DIMENSION OF CANCER 61 4 The Logic of Cancer Treatment: Why It Is So Hard to Cure Cancer; Treatment-Induced Progression, Hyper-Progression, and the Nietzsche Effect 635 The Cell Attractor Concept as a Tool to Advance Our Understanding of Cancer 1296 Adaptation of Molecular Interaction Networks in Cancer Cells 1417 The Role of Genomic Dark Matter in Cancer: Using AI to Shine a Light on It; Why Cancer Genes Are Not the Whole Story 163III THE TIME DIMENSION OF CANCER 185 8 Darwinism, Not Mutationalism, for New Cancer Therapies 187 9 Cancer as a Reversion to an Ancestral Phenotype 20510 Time and Timing in Oncology: What Therapy Scheduling Can Teach Us about Cancer Biology 227IV THE MICRO-/ENVIRONMENT DIMENSION OF CANCER 245 11 Tissue Tension Modulates Metabolism and Chromatin Organization to Promote Malignancy 24712 Cancer Metabolism and Therapeutic Perspectives: Exploiting Acidic, Nutritional, and Oxidative Stresses 27113 Corrupted Vascular Tumor Niches Confer Aggressiveness and Chemoresistance to Neoplastic Cells 29914 Metastasis as a Tug of War between Cell Autonomy and Microenvironmental Control: Readdressing Unresolved Questions in Cancer Metastasis 32315 Niche Reconstruction to Revert or Transcend the Cancer State 353V WHAT NEXT? 391Contributors 397 Index 399 Promotional "Headline" Leading scientists propose a new paradigm for cancer research, presenting new theory frameworks based on complex systems and supported by empirical evidence. Details ISBN0262045214 Short Title Rethinking Cancer Series Vienna Series in Theoretical Biology Language English Year 2021 ISBN-10 0262045214 ISBN-13 9780262045216 Format Hardcover Edited by Bissell, Mina J. Author Marta Bertolaso Publication Date 2021-04-27 Pages 376 UK Release Date 2021-04-27 Imprint MIT Press Country of Publication United States AU Release Date 2021-04-27 NZ Release Date 2021-04-27 US Release Date 2021-04-27 Birth 1954 Death 1939 Affiliation G.R.E.Q.A.M. Position Associate Professor of Operations Management Qualifications Ph.D. Illustrations 34 black and white illustrations Publisher MIT Press Ltd Subtitle A New Paradigm for the Postgenomics Era DEWEY 616.994042 Audience General We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:131766191;
Price: 123.59 AUD
Location: Melbourne
End Time: 2024-11-08T02:26:27.000Z
Shipping Cost: 0 AUD
Product Images
Item Specifics
Restocking fee: No
Return shipping will be paid by: Buyer
Returns Accepted: Returns Accepted
Item must be returned within: 30 Days
ISBN-13: 9780262045216
Book Title: Rethinking Cancer
Subject Area: Bioengineering
Item Height: 229 mm
Item Width: 178 mm
Author: Marta Bertolaso, Bernhard Strauss
Publication Name: Rethinking Cancer: a New Paradigm for the Postgenomics Era
Format: Hardcover
Language: English
Publisher: MIT Press Ltd
Subject: Medicine, Engineering & Technology, Biology
Publication Year: 2021
Type: Textbook
Number of Pages: 376 Pages
