Description: Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases by Takuya Hidaka Estimated delivery 3-12 business days Format Hardcover Condition Brand New Description This book describes the authors work on the development of sequence-specific DNA binders for the therapy of mitochondrial diseases. In the first chapter, the author provides a detailed background of pyrrole–imidazole polyamides (PIPs) and mitochondrial disease research followed by chapters presenting the authors own research and discoveries. Firstly, the developed compounds called MITO-PIPs, which recognize specific sequences in mitochondrial DNA, are presented. The following chapter demonstrates how, by introducing a DNA alkylating reagent into a MITO-PIP that recognizes the adjacent sequence to a target mutation, the copy number of mutated mitochondrial DNA was successfully reduced in live cells. Furthermore, because nuclear DNA is another important target for treating mitochondrial diseases, the author demonstrated that tri-arginine vectors can enhance nuclear uptake of PIPs and improve their biological activity in cells.This work willattract readers interest because it paves the way for a transgene-free chemical gene therapy for mitochondrial diseases. The book includes a detailed description of experimental procedures, especially compound synthesis. This description helps readers to have a clear image of the authors studies and to perform similar and extended studies themselves. Author Biography Takuya Hidaka received his Ph.D. in 2021 under the supervision of Professor Hiroshi Sugiyama at Kyoto University for his chemical biology research on artificial control of DNA transcription and replication using DNA-binding molecules. He has been a research fellow of the Japan Society for the Promotion of Science (JSPS) from 2021 and is working on the development of proteome analysis techniques based on single-molecule imaging. Details ISBN 9811684359 ISBN-13 9789811684357 Title Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases Author Takuya Hidaka Format Hardcover Year 2022 Pages 94 Edition 1st Publisher Springer Verlag, Singapore GE_Item_ID:140227113; About Us Grand Eagle Retail is the ideal place for all your shopping needs! With fast shipping, low prices, friendly service and over 1,000,000 in stock items - you're bound to find what you want, at a price you'll love! Shipping & Delivery Times Shipping is FREE to any address in USA. Please view eBay estimated delivery times at the top of the listing. Deliveries are made by either USPS or Courier. We are unable to deliver faster than stated. International deliveries will take 1-6 weeks. NOTE: We are unable to offer combined shipping for multiple items purchased. This is because our items are shipped from different locations. Returns If you wish to return an item, please consult our Returns Policy as below: Please contact Customer Services and request "Return Authorisation" before you send your item back to us. Unauthorised returns will not be accepted. Returns must be postmarked within 4 business days of authorisation and must be in resellable condition. Returns are shipped at the customer's risk. We cannot take responsibility for items which are lost or damaged in transit. For purchases where a shipping charge was paid, there will be no refund of the original shipping charge. Additional Questions If you have any questions please feel free to Contact Us. Categories Baby Books Electronics Fashion Games Health & Beauty Home, Garden & Pets Movies Music Sports & Outdoors Toys
Price: 211.95 USD
Location: Fairfield, Ohio
End Time: 2024-09-19T03:36:07.000Z
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Restocking Fee: No
Return shipping will be paid by: Buyer
All returns accepted: Returns Accepted
Item must be returned within: 30 Days
Refund will be given as: Money Back
ISBN-13: 9789811684357
Type: NA
Publication Name: NA
Book Title: Sequence-Specific D N A Binders for the Therapy of Mitochondrial Diseases
Number of Pages: Xiii, 94 Pages
Language: English
Publisher: Springer
Topic: Materials Science / General, Life Sciences / Cell Biology, Life Sciences / Anatomy & Physiology (See Also Life Sciences / Human Anatomy & Physiology), Life Sciences / Genetics & Genomics
Publication Year: 2022
Illustrator: Yes
Genre: Technology & Engineering, Science
Item Weight: 11.9 Oz
Author: Takuya Hidaka
Item Length: 9.3 in
Item Width: 6.1 in
Book Series: Springer Theses Ser.
Format: Hardcover
