Description: Transporters in Drug Development : Discovery, Optimization, Clinical Study and Regulation, Paperback by Sugiyama, Yuichi (EDT); Steffansen, Bente (EDT), ISBN 1493952064, ISBN-13 9781493952069, Like New Used, Free shipping in the US Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. Th describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and th highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.
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Book Title: Transporters in Drug Development : Discovery, Optimization, Clinical Study and Regulation
Number of Pages: Xiii, 317 Pages
Language: English
Publisher: Springer New York
Publication Year: 2016
Topic: Life Sciences / Molecular Biology, Pharmacy, Pharmacology, Research, Chemistry / Organic
Item Height: 0.7 in
Illustrator: Yes
Genre: Science, Medical
Item Weight: 179.7 Oz
Item Length: 9.2 in
Author: Bente Steffansen
Book Series: Aaps Advances in the Pharmaceutical Sciences Ser.
Item Width: 6.1 in
Format: Trade Paperback
